Johns Hopkins Manual for GI Endoscopic Nurses, Third Edition

Mouen Khashab, MD; Toshunia Robinson, MD; Anthony Kalloo, MD

Chapter 52: Secretin Stimulation Study (continued)

Mouen A . Khashab, MD

The secretin stimulation study is performed in the GI laboratory to detect the presence of Zollinger-Ellison syndrome (gastrinoma). This is a nonbeta islet cell tumor of the pancreas, which causes large amounts of gastrin to be secreted into the blood stream. Three primary characteristics of this disease are severe peptic ulcer formation in unusual locations, gastric hypersecretion of gigantic proportions, and nonspecific islet cell tumors of the pancreas. Thickened folds of the stomach and chronic diarrhea are also prominent symptoms, but may be indicative of other diseases. Most patients…