Johns Hopkins Manual for GI Endoscopic Nurses, Third Edition

Mouen Khashab, MD; Toshunia Robinson, MD; Anthony Kalloo, MD

Chapter 12: Confocal Laser Endomicroscopy (continued)

Marcia Irene Canto, MD, MHS

Confocal laser endomicroscopy (CLE) is an endoscopic procedure that enables the surface of the intestinal or gastric mucosa to be examined microscopically in vivo during the endoscopy. CLE enables visualization of the cellular, vascular, and connective structures with maximum magnifying power of 1000x. It also enables quantitative measurements of surface mucosa in both lateral and vertical dimensions. Using point scanning laser analysis, the physician is able to have a real-time diagnosis of different GI conditions such as Barrett’s esophagus, esophageal and gastric cancer…