Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions

Douglas G. Adler, MD

Question 29: What Is The Role Of Photodynamic Therapy And Brachytherapy In Patients With Cholangiocarcinoma? (continued)

Ananya Das, MD, FACG, FASGE

Most cholangiocarcinomas (CCAs) are extrahepatic; approximately 60% to 70% are located in the hilar area (also known as Klatskin’s tumors), and approximately 20% to 30% are located more distally, involving the common bile duct. Surgical treatment offers the only chance for cure for CCA, but only a minority of patients are surgical candidates. Even for these patients, an R0 resection is feasible in only about 30% of instances, and 5-year survival rates after R0 resection for hilar CCA are 10% to 40%, and for distal extrahepatic CCA are 25% to 40%. In patients with primary sclerosing…