Gut Instincts: A Clinician's Handbook of Digestive and Liver Diseases

Eric Esrailian, MD, MPH

Chapter 26: Clostridium Difficile (continued)

Theodoros Kelesidis, MD; Charalabos Pothoulakis, MD

Clostridium difficile infection (CDI) represents the most common diarrheal infection in hospitals, affecting millions of patients annually in the United States and abroad. C. difficile has been identified as the pathogen causing pseudomembranous colitis and is emerging as one of the most significant hospital-acquired infections. The diagnosis of CDI is based on a combination of clinical and laboratory findings. These include the passage of 3 or more unformed stools per day and a stool test result positive for the presence of C. difficile or its toxins. Less frequently, endoscopic or…