Probiotics: A Clinical Guide

Martin H. Floch, MD; Adam S. Kim, MD

Chapter 14: Probiotics And Their Role In Antibiotic-Associated Diarrhea And Clostridium Difficile Infection (continued)

Laurel H. Hartwell, MD; Christina M. Surawicz, MD, MACG

Diarrhea is a common side effect of antibiotic use, ranging from 10% to 30% in the outpatient setting and as high as 39% in hospitalized patients. There has been increased interest in the role of probiotics in prevention of AAD over the past 2 decades. AAD is defined as diarrhea that occurs during or shortly after antibiotic use, even up to 2 to 4 weeks after their discontinuation. Any antibiotic can cause diarrhea, but increasing use of broad-spectrum antibiotics, such as amoxicillin, ampicillin, cephalosporins, and clindamycin, has been identified as a risk factor for developing AAD.