Curbside Consultation in IBS: 49 Clinical Questions

Brian E. Lacy, PhD, MD

Question 12: What is the Pathophysiology of IBS? (continued)

Lisa Shim, MB BS, FRACP; John E. Kellow, MD, FRACP

Although irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders, its actual cause remains unknown. Over the past decades, however, new areas of research have improved our understanding of IBS considerably and have provided increasing evidence that its pathophysiology is complex and multifactorial. Today, IBS is no longer considered merely a psychosomatic condition but is best understood from a bio-psychosocial perspective characterized by prominent dysregulation of the brain- gut axis. The central nervous system communicates with the enteric nervous system of the…