Curbside Consultation in IBS: 49 Clinical Questions

Brian E. Lacy, PhD, MD

Question 22: How Common is Celiac Disease in Patients With IBS? (continued)

Joseph Y. Chang, MD, MPH; Yuri A. Saito-Loftus, MD, MPH

Irritable bowel syndrome (IBS) is a common functional gastrointestinal (GI) disorder that is estimated to affect 15% of the population and is characterized by abdominal pain/discomfort with a concurrent disturbance in defecation. In contrast to IBS, celiac disease (CD) is an autoimmune inflammatory enteropathy of the small intestine caused by intolerance to gluten with a prevalence of approximately 1% in the community. Unlike IBS, untreated CD can result in morphologic changes in the small intestinal mucosa that may lead to villous atrophy and malabsorption, and CD patients have higher…