Curbside Consultation in IBS: 49 Clinical Questions

Brian E. Lacy, PhD, MD

Question 13: Are there Risk Factors for Developing IBS? (continued)

Peter Paine, MD, PhD, MRCP; Lesley A. Houghton, PhD, FSB, FACG, AGAF

What might be a risk factor for IBS is highly inter- related to its possible cause. To date, however, a precise cause has remained elusive, although multiple possible interactions have been identified. It is, therefore, not surprising that there are a number of potential risk factors for the development of IBS. Identification of these possible risk factors has come primarily from epidemiology studies, from twin/family studies, from studying postinfectious IBS (PI- IBS), and from information gleaned from pre clinical human and animal models of IBS. Given the etiological heterogeneity of IBS…