Alosetron is a potent selective 5-HT
3 (serotonin) receptor antagonist. Its physiologic effects on the gastrointestinal tract include slowing colonic transit, decreasing visceral sensation, and increasing fluid absorption in the small intestine. Its efficacy in the treatment of women suffering from irritable bowel syndrome with diarrhea (IBS-D) has been proven in several high-quality randomized, placebo-controlled clinical trials.
1 Alosetron is superior to placebo in providing adequate relief of pain and discomfort, control of urgency, decreased stool frequency, and increased stool…