Curbside Consultation of the Colon: 49 Clinical Questions

Brooks D. Cash, MD, FACP, CDR, MC, USN

Question 27: I Want To Use Alosetron For A Woman With Ibs-D. What Do I Need To Tell Her About The Risks And Outcomes Associated With Ischemic Colitis And This Medicine? What Is The Best Way To Document This Discussion? (continued)

Richard Saad, MD

Alosetron is a potent selective 5-HT3 (serotonin) receptor antagonist. Its physiologic effects on the gastrointestinal tract include slowing colonic transit, decreasing visceral sensation, and increasing fluid absorption in the small intestine. Its efficacy in the treatment of women suffering from irritable bowel syndrome with diarrhea (IBS-D) has been proven in several high-quality randomized, placebo-controlled clinical trials.1 Alosetron is superior to placebo in providing adequate relief of pain and discomfort, control of urgency, decreased stool frequency, and increased stool…