Ulcerative Colitis: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 27: Medical Management of Toxic Megacolon in the Patient with Ulcerative Colitis (continued)

Robynne Chutkan, MD; Nabil Toubia, MD

MEDICAL MANAGEMENT OF TOXIC MEGACOLON IN THE PATIENT WITH ULCERATIVE COLITIS Toxic megacolon is an infrequent but potentially fatal complication of inflammatory bowel disease (IBD). It was first recognized as a clinical entity by Marshak et al1 in 1950, with the term toxic megacolon coined by Roth et al in 1959.2 It is defined as segmental or total colonic distention of 6 cm or more in the setting of acute colitis associated with signs and symptoms of systemic toxicity.3,4 Other conditions predisposing to toxic megacolon have been reported since its initial description in patients with…