Curbside Consultation in IBD: 49 Clinical Questions, Second Edition

David T Rubin, MD; Sonia Friedman, MD; Francis A Farraye, MD MSc

Question 28: How Do You Handle An Inflammatory Bowel Disease Patient With Clostridium Difficile Infection? (continued)

David G. Binion, MD

It is not uncommon to encounter inflammatory bowel disease (IBD), Crohn’s disease (CD), or ulcerative colitis (UC) patients experiencing clinical flare and, in the course of evaluation, finding a stool enzyme-linked immunosorbent assay (ELISA) or polymerase chain reaction (PCR) test positive for Clostridium difficile. In past years, C difficile was felt to be a rare contributing factor for flare in the setting of IBD, but this is no longer the case. It is essential for clinicians to be aware of C difficile and its potential role in the unexpected deterioration of a stable IBD patient…