Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 6: The Limitations of Applying Evidence-Based Medicine to Inflammatory Bowel Disease: What We Do Not Learn from Clinical Trials (continued)

Joshua R. Korzenik, MD; Corey A. Siegel, MD

The protean nature of inflammatory bowel disease (IBD) complicates the process of determining the applicability of trial results to an individual patient. The peculiarities of a particular study often are not generalizable to broader situations. The specific question that a study is designed to answer may not be applicable to the immediate dilemma facing the clinician. The inclusion and exclusion criteria for a study referred to for guidance may have excluded the patient that the physician is assessing for treatment. For instance, the medications a patient is taking or his or her level of…