Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 9: Medication Adherence in Inflammatory Bowel Disease (continued)

Sunada Kane, MD, MSPH, FACG, FACP, AGAF

Multiple studies have demonstrated the efficacy of aminosalicylates as first-line therapy to induce and maintain remission in ulcerative colitis.1-5 These well-designed multicenter trials have used pill count and patient inquiry to assess adherence, with rates ranging from 70% to >95%. Based upon community-based follow-up studies in other chronic illnesses, the percentage of long-term adherence tends to be much lower, about 40% to 50%.6 This wide variance across studies can be explained by 1) a study’s definition of adherence, 2) the degree to which the investigators were proactive…
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