Ulcerative Colitis: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 2: Clinical Research in Inflammatory Bowel Disease (continued)

Chinyu Su, MD; James D. Lewis, MD, MSCE

CLINICAL RESEARCH IN INFLAMMATORY BOWEL DISEASE PLACEBO RESPONSE IN CLINICAL TRIALS A major goal of clinical research is to identify new therapies for the treatment of disease. In addition, research is used to define the potential risks of therapeutic interventions. In the realm of inflammatory bowel disease (IBD), there has been an enormous explosion in our knowledge of the underlying cause of these diseases and in development of therapeutic interventions. This chapter will provide a brief overview of the design and interpretation of clinical trials, with a focus on the role of placebo…