Curbside Consultation in IBD: 49 Clinical Questions, Second Edition

David T Rubin, MD; Sonia Friedman, MD; Francis A Farraye, MD MSc

Question 11: How Often Does Celiac Disease Coexist With Inflammatory Bowel Disease? (continued)

Ciaran Kelly, MD; Toufic Kabbani, MD

Celiac disease and inflammatory bowel disease (IBD) can coexist, and studies suggest that there is an increased risk of celiac disease in IBD patients. In a small study of 27 patients with newly diagnosed Crohn’s disease (CD), 5 patients (18.5%) were found to have biopsy-proven celiac disease. Similarly, celiac disease patients are at increased risk for both ulcerative colitis (UC) and CD. However, the association between celiac disease and UC is stronger (5-fold increased risk). Recent genome-wide association studies in celiac disease and UC showed overlap between genes…