Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 1: The Natural History of Inflammatory Bowel Disease (continued)

Pietro G. Andres, MD; Lawrence S. Friedman, MD

UC and CD are at least partially distinct in their initial pathogenic events, but they may have key pathophysiologic processes in common. Moreover, UC and CD each may encompass several variants, which are at least partially distinct. For example, patients with CD may manifest different complications (fistulas or stenoses) and may express different inflammatory mediators, perhaps due to underlying genetic differences or environmental exposures between the two groups. Thus, patient subgroups defined by disease location, specific pathologic findings (the presence or absence of granulomas in…