Clinical Challenges and Complications of IBD

Miguel D Regueiro, MD; Jason Swoger, MD MPH

Chapter 6: Infections In IBD - Clostridium difficile and Cytomegalovirus (continued)

Ashwin N. Ananthakrishnan, MD, MPH

Inflammatory bowel diseases (IBDs), comprising Crohn’s disease (CD) and ulcerative colitis (UC), are lifelong immunologically mediated disorders affecting the gastrointestinal tract. With an onset often during young adulthood, IBD has a relapsing-remitting course. The majority of relapses relate to the underlying disease, but in a significant proportion of patients, disease flares are triggered by, or are due to, superimposed gastrointestinal infections. The 2 most well recognized among such infections are those due to Clostridium difficile and cytomegalovirus (CMV). The past 2…