Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 4: Utility of Animal Models for the Study and Treatment of Inflammatory Bowel Disease (continued)

Ashish Chawla, MD; Kenneth Simpson, BVM&S, PhD

IBD develops in approximately 0.1% of the Western population, but the etiology and pathogenesis of the disease is unknown. During the past decade, UC and CD have gained increased importance because of increased incidence and prevalence. Older treatment modalities are largely nonspecific and just alleviate the symptoms without altering the natural history of the disease. Therefore, murine models of colitis have been developed to study the pathogenesis, genetics, and treatment of colitis. These models have increased our knowledge of mucosal inflammation and have led to the development of…