Curbside Consultation in IBD: 49 Clinical Questions, Second Edition

David T Rubin, MD; Sonia Friedman, MD; Francis A Farraye, MD MSc

Question 12: What Endpoints Should We Aim For In Inflammatory Bowel Disease Medical Therapy? (continued)

Gert Van Assche, MD, PhD; Marc Ferrante, MD, PhD

Crohn’s disease (CD) is a progressive disease and, to a lesser extent, may apply to ulcerative colitis (UC). Repeated cycles of clinical activity and remission are observed in most patients, but it is likely that chronic mucosal inflammation is present even in many symptom-free patients. Chronic mucosal inflammation extends transmurally in patients with CD and leads to the most commonly observed complications: strictures and fistulae. These complications necessitate surgery, which, in turn, can lead to loss of function or need for permanent ostomy. Accumulating evidence suggests that…