Clinical Challenges and Complications of IBD

Miguel D Regueiro, MD; Jason Swoger, MD MPH

Chapter 5: Dysplasia And Colorectal Cancer (continued)

Fernando Velayos, MD, MPH

Colorectal cancer (CRC) is a feared complication of inflammatory bowel disease (IBD). This chapter reviews the most important risk factors for its development, as well as potential strategies for reducing these risks. The cumulative probability of developing CRC is significantly higher among persons with IBD than in the general population.1,2 IBD is the third highest risk condition for CRC after 2 genetic syndromes: familial adenomatous polyposis syndrome and hereditary nonpolyposis CRC.3 Data from a comprehensive meta-analysis suggest that the…