Ulcerative Colitis: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 19: Azathioprine Metabolism in Inflammatory Bowel Disease (continued)

Carmen Cuffari, MD

AZATHIOPRINE METABOLISM IN INFLAMMATORY BOWEL DISEASE A PHYSICIAN’S GUIDE TO METABOLITE TESTING Critical-dose drugs are therapeutic agents that demonstrate a wide inter-patient variability in drug metabolism.1 These inherent differences in pharmacokinetics are perceived to influence patient responsiveness to therapy and patient susceptibility to drug-induced cytotoxicity.2,3 6-MP and its prodrug AZA are 2 examples of critical-dose drugs that are well-known for their immunosuppressive and lymphocytotic effects in the management of patients with lymphoma and leukemia. Their…