Pocket Guide to IBD, Second Edition

Marla Dubinsky, MD; Sonia Friedman, MD

Chapter 11: Anti-Tumor Necrosis Factor Therapy And Management (continued)

Kim L. Isaacs, MD, PhD

Currently, 3 anti-tumor necrosis factor (TNF) therapies are available for use in IBD. These are infliximab, adalimumab, and certolizumab. The pretreatment evaluation protocol is similar for each of these anti-TNF agents. However, a few differences in management of these therapies exist due to the different routes and timing of administration of the available anti-TNF agents. • Perform a tuberculosis skin test (purified protein derivative [PPD]) to rule out latent tuberculosis (TB). If the potential risk of prior TB exposure is high and the patient is likely to be anergic, consider…