Curbside Consultation in Endoscopy: 49 Clinical Questions, Second Edition

Joseph Leung, MD; Simon Lo, MD

Question 31: My Accountant, Whose Ulcerative Colitis Is In Good Control On Maintenance 5 Asa Therapy, Called Because His Lfts Were Elevated. He Had No History Of Jaundice, But New Onset Of Itching. What Should I Do? (continued)

Andrew Yen, MD; Joseph Leung, MD, FRCP, FACP, FASGE, MACG

The approach to the patient with inflammatory bowel disease (IBD) and abnormal liver function tests (LFTs) starts with accurate interpretation of liver biochemical tests in the context of a carefully obtained history and thorough physical examination. The pattern and severity of LFT abnormalities can provide important clues in the differential diagnosis of underlying disease. A cholestatic pattern of injury and the development of pruritus in this patient with ulcerative colitis (UC) suggest the possibility of an underlying pancreaticobiliary disorder, including primary sclerosing cholangitis…