Curbside Consultation of the Liver: 49 Clinical Questions

Mitchell L. Shiffman, MD

Question 8: How Often Should I Follow A Patient Who Had Chronic Hepatitis C After He Achieved A Sustained Virologic Response? (continued)

Mitchell L. Shiffman, MD

Traditionally, a sustained virologic response (SVR) is defined as being hepatitis C virus (HCV) RNA undetectable 6 months after peginterferon and ribavirin are discontinued.1 In the past it was unclear how long these patients remained HCV RNA undetectable or whether SVR was maintained long term and these patients were truly “cured” of HCV. No formal recommendations existed as to how these patients should be monitored. As a result, our practice, along with many other gastroenterologists, was to have these patients return once yearly to measure HCV RNA and to ensure that they…