Curbside Consultation in GI Cancer for the Gastroenterologist: 49 Clinical Questions

Douglas G. Adler, MD

Question 30: What Are The Risk Factors For The Development Of Hepatocellular Cancer? (continued)

Ravinder R. Kurella, MD; William M. Tierney, MD

There are about 8000 new cases of hepatocellular cancer (HCC) diagnosed in the United States each year. Worldwide, HCC accounts for more than 1 million deaths annually and is likely the third most common cause of cancer death.1 The various risk factors for the development of HCC can be divided into the following categories: chronic viral hepatitis, chronic liver disease other than viral hepatitis, genetic disorders, and dietary and environmental risk factors. Chronic hepatitis B virus (HBV) is the most common cause of HCC worldwide.2 The risk appears to be related to chronic inflammation as…