Common Liver Diseases and Transplantation: An Algorithmic Approach to Work Up and Management

Robert S Brown Jr, MD MPH

Chapter 6: Hepatitis B Virus (continued)

Blaire E. Burman, MD; Robert S. Brown Jr, MD, MPH

Hepatitis B is the most prevalent liver disease worldwide. More than 2 billion individuals have been infected with HBV and an estimated 350 to 400 million people are living with chronic infection, as identified by the persistence of hepatitis B surface antigen (HBsAg) positivity after initial exposure.1 Each year over 1.2 million deaths are attributable to the consequences of hepatitis B: cirrhosis, liver failure, and hepatocellular carcinoma (HCC). In the United States, considered a low-prevalence country, nearly 1.4 million are known to have chronic hepatitis B (CHB) yet it is estimated…