Gut Instincts: A Clinician's Handbook of Digestive and Liver Diseases

Eric Esrailian, MD, MPH

Chapter 33: Hepatitis B (continued)

Vandana Khungar, MD, MSc; Steven-Huy Han, MD, AGAF

More than 400 million people worldwide have chronic hepatitis B (CHB) infection. Up to 50% of the world’s population has had hepatitis B virus (HBV) infection based on hepatitis B surface antibody (HBsAb) prevalence. HBV is endemic in countries that make up 45% of the world’s population. In the United States, the prevalence of CHB infection is 0.1% to 0.2% (1.25 million), and the annual incidence of new infections is 200,000 to 300,000. HBV is transmitted mainly by perinatal, percutaneous, and sexual routes. In the United States, HBV is usually contracted via sexual or…