Curbside Consultation of the Liver: 49 Clinical Questions

Mitchell L. Shiffman, MD

Question 1: What Is The Likelihood That My Patient With Chronic Hepatitis C Will Develop Cirrhosis, Hepatocellular Carcinoma, And/Or Hepatic Decompensation? (continued)

Seela Ramesh, MD ; Mitchell L. Shiffman, MD

Approximately 4 million persons within the United States are infected with the hepatitis C virus (HCV). Chronic HCV is the most common cause of cirrhosis and hepatocellular carcinoma (HCC), and over 40% of all patients who undergo liver transplantation in the United States, Europe, Canada, Australia, and many countries have chronic HCV infection.1 Despite this, the natural history of chronic HCV has a wide spectrum. Only 4% of persons with chronic HCV develop end-stage liver disease and/or HCC and need to consider liver transplantation as a therapeutic option (Figure