Curbside Consultation of the Liver: 49 Clinical Questions

Mitchell L. Shiffman, MD

Question 9: Which Patients With Chronic Hepatitis B Require A Liver Biopsy? (continued)

Wei Hou, MD; Mitchell L. Shiffman, MD

Hepatitis B virus (HBV) infection is a significant global health issue that affects over 2 billion persons worldwide. In the United States, approximately 1.25 million persons have chronic infection and approximately 150,000 new infections are recorded each year. Individuals infected with HBV go through a series of serologic steps, which either results in spontaneous resolution of this virus and the development of protective hepatitis B surface antibodies (anti-HBs) or chronic HBV infection where hepatitis B surface antigen (HBsAg) persists in serum. Almost immediately after becoming infected…