Common Liver Diseases and Transplantation: An Algorithmic Approach to Work Up and Management

Robert S Brown Jr, MD MPH

Chapter 8: Alcoholic And Nonalcoholic Fatty Liver Disease (continued)

Scott A. Fink, MD, MPH, FACP

Alcoholic liver disease and nonalcoholic liver disease both represent spectrums of liver disease united by similar patterns of progression and pathology but are divided by different inciting factors. Alcohol can induce hepatic steatosis in a subset of the population. In nonalcoholic fatty liver disease (NAFLD), insulin resistance contributes to the development of hepatic steatosis. Both processes can in turn lead to inflammatory changes among hepatocytes followed by progression of fibrosis until the liver becomes cirrhotic. The spectrum of disease in both alcoholic and nonalcoholic liver…