Curbside Consultation in GERD: 49 Clinical Questions

Philip O. Katz, MD

Question 49: I Know That Reflux And Eosinophilic Esophagitis Can Lead To Dysphagia And Eosinophils On Esophageal Biopsy. How Do I Differentiate These Two Diseases? (continued)

Eosinophilic esophagitis is a disease process seen more frequently in adults over the past 5 to 10 years. In its classic presentation, it is seen in young men with recurrent intermittent solid food dysphagia and a history of food impaction. As the disease is discovered in increased frequency, the diagnosis is being entertained and made in adults of any age, gender, and ethnic background with unexplained dysphagia, chest pain, and refractory reflux symptoms. It is in the latter 2 clinical situations that the differentiation between reflux disease and eosinophilic esophagitis becomes a clinical…