Curbside Consultation in GERD: 49 Clinical Questions

Philip O. Katz, MD

Question 24: What Are The Short- And Long-Term Risks Of Proton Pump Inhibitor Therapy? Are Any Risks Of Clinical Importance? (continued)

These agents are among the safest used in medicine (Figure 24-1). Headache, abdominal pain, and diarrhea are the most common side effects and these are seen in no greater frequency than placebo in clinical trials. Concerns regarding long-term acid suppression and an increase in gastric carcinoid tumors have not been seen. Fundic gland polyps are seen in a small percentage of patients on proton pump inhibitor (PPI); however, to date the polys have universally been shown to have benign histology and are not a risk for “bad” outcomes. Though careful observational and case-control…