GI and Liver Disease During Pregnancy: A Practical Approach

Kim L Isaacs, MD PhD; Millie D Long, MD MPH

Chapter 1: Gastroesophageal Reflux Disease In Pregnancy (continued)

Ryan D. Madanick, MD

Heartburn, or pyrosis, is the cardinal symptom of gastroesophageal reflux disease (GERD) and occurs in up to 80% of women during pregnancy.1 Heartburn can occur during any trimester of the pregnancy. The onset of heartburn in pregnancy occurs in the first trimester in 22% to 52% of women, and the prevalence of heartburn increases with gestational age.2,3 Atypical symptoms of GERD such as cough, chest pain, and globus also occur with higher frequency than in the prepregnancy state.4 Because of the high prevalence of heartburn and GERD in…