Gut Instincts: A Clinician's Handbook of Digestive and Liver Diseases

Eric Esrailian, MD, MPH

Chapter 5: Barrett's Esophagus (continued)

Bennett E. Roth, MD

Barrett’s esophagus (BE) is defined as the metaplastic replacement of the squamous esophageal mucosal surface by intestinalized columnar mucosa. Although originally inclusive of any columnar mucosal changes in the esophagus, it is only that associated with intestinalization (intestinal metaplasia) of the columnar cells that carries the risk of cancer and should be considered Barrett’s mucosa. Intestinal metaplasia can occur in the gastric cardia and must be distinguished from that arising in the true esophagus because the former, which may be a marker for underlying…