Extraesophageal Manifestations of GERD

Anthony J DiMarino Jr, MD; Sidney Cohen, MD

Chapter 3: Pulmonary Manifestations of GERD Controversies and Consensus (continued)

Lindsey B. Roenigk, MD; Susan M. Harding, MD

Since the 12th century, physicians have noted that gastroesophageal reflux (GER) symptoms are temporally associated with respiratory symptoms.1 GER causes cough, triggers asthma, and can impact other pulmonary diseases.2 Recent data provide further insight into the association of GER and pulmonary disease. PATHOPHYSIOLOGICAL MECHANISMS OF GASTROESOPHAGEAL REFLUX-INDUCED PULMONARY DISEASE The lung and the esophagus share common embryonic foregut origins and vagal innervation.2 Esophageal acid initiates vagally mediated reflexes, resulting in bronchoconstriction.