Curbside Consultation of the Colon: 49 Clinical Questions

Brooks D. Cash, MD, FACP, CDR, MC, USN

Question 29: My Patient With Collagenous Colitis Developed A Black Tongue With Bismuth. What Other Therapeutic Options Do I Have? (continued)

Richard Saad, MD

Collagenous colitis represents one of the two major forms of microscopic colitis. This is an idiopathic, chronic condition marked by nonbloody, watery diarrhea and characteristic histologic abnormalities on mucosal biopsy. Associated symptoms may include occasional fecal incontinence, abdominal cramping, nausea, weight loss, and abdominal distention. Endoscopy and radiographic studies are normal, and laboratory studies are generally unremarkable as well. The mucosal abnormalities of collagenous colitis include a thickened linear subepithelial collagen layer and frequently a mononuclear…