Curbside Consultation of the Pancreas: 49 Clinical Questions

Scott Tenner, MD, MPH; Alphonso Brown, MD, MS Clin Epi; Frank Gress, MD

Question 35: My Patient Has Chronic Diarrhea And Extensive Work-Up Has Been Negative. How To Establish A Diagnosis In A Patient Suspected Of Having Vipoma? (continued)

Jack P. Braha, DO; Nison Badalov, MD; Robin Baradarian, MD, FACG

Vasoactive intestinal peptide (VIP) is a peptide that inhibits gastric acid secretion in the stomach. In the small bowel, it stimulates chloride secretion and smooth muscle contraction. Other functions of VIP include serving as a neurotransmitter as well as modulator in potentiating the activity of acetylcholine in the salivary glands. As its name implies, VIP serves as a vasodilator elsewhere in the body including the coronary arteries. VIP acts on the myocardium as a positive inotrope and chronotrope. During its circulation throughout the bloodstream, VIP has a half-life of approximately 2…