Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 12: Corticosteroids in Crohn's Disease (continued)

Lene Riis, MD; Pia Munkholm, MD, DMSCi

The potent anti-inflammatories were first described in rheumatoid arthritis patients in 1949, which led to clinical trials in numerous other chronic inflammatory disorders, including IBD.1 Since the beginning of the 1950s, we have learned from Weedon and colleagues’ data2 that corticosteroids have had a great impact on survival. Identical data were obtained when surgery was introduced in this decade.3 Cumulative survival rates declined 20% over the following 20 years after the introduction of corticosteroids in Crohn’s disease (Figure 12-1). The first…