KEY POINTS

Clinical studies using probiotics have been disappointing.

Acupuncture may be of benefit.

Patients with Crohn's disease (CD) should be screened for micronutrient deficiencies.

Data supporting the use of complementary and alternative medicine in CD are scanty. PROBIOTICS
1 A dysfunctional mucosal barrier
2 with or without an alteration of bacterial composition has the potential to allow luminal bacterial antigens to initiate the chronic inflammatory cascade in CD. Studies using probiotics in CD have largely been disappointing.
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