Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 20: Novel Nonbiologic Therapy for Crohn’s Disease (continued)

Masayuki Fukata, MD, PhD; Maria T. Abreu, MD

Crohn’s disease is a chronic inflammatory bowel disease (IBD) whose etiology remains elusive. The first gene, CARD15/NOD2, associated with susceptibility to CD was identified in 2001.1,2 CARD15/NOD2 encodes a cytoplasmic protein expressed by monocyte/macrophages3 and Paneth cells.4 More recently, a second set of genes previously known as IBD5 and now recognized as organic cation transporters have also been identified as CD-susceptibility genes.5 Carriage of mutations in both CARD15/NOD2 and OCTN increases the risk of CD greatly. Through the advances in our understanding of CD…