Curbside Consultation in IBD: 49 Clinical Questions, Second Edition

David T Rubin, MD; Sonia Friedman, MD; Francis A Farraye, MD MSc

Question 1: How Can We Assess Prognosis In Crohn’S Disease? (continued)

Marla C. Dubinsky, MD

Individuals with Crohn’s disease (CD) show a wide variation in the way they present and progress over time. Some patients present with mild disease activity and do well with generally safe and mild medications. However, many exhibit more severe disease with an impaired quality of life, continued active gastrointestinal (GI) symptoms, and the eventual development of disease complications requiring surgery. Current and emerging potent therapies that target the immune system help decrease symptoms and appear to decrease the need for surgery. However, these therapies have increased the…