Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 21: Assessment of Disease Activity in Crohn’s Disease (continued)

A problem that arises when defining disease activity is the discrepancy between presence of bowel inflammation and patient well-being. Biologic, endoscopic, histologic, or radiologic indicators of inflammation that reflect ongoing intestinal disease activity may be heightened in patients who systemically feel otherwise well. The significance of these indicators in the context of subclinical disease is unclear although their increase may herald an impending clinical relapse. Furthermore, whether the normalization of these parameters (even if related to subclinical disease) should be a goal of…