Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 37: Maintenance Therapy of Crohn’s Disease (continued)

Wojciech Blonski, MD, PhD; Faten Aberra, MD, MSCE; Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Once a patient has achieved remission by means of medical therapy, the risk of relapse is high if treatment is not continued. Several studies have demonstrated Crohn’s disease (CD) relapse rates as high as 71% to 85% after 1 year in patients who were maintained on mesalamine or placebo after treatment with corticosteroids to induce remission.1,2 Several medical therapies have been investigated for use in maintenance of remission of CD and include 5-aminosalicylates (5-ASA), corticosteroids, budesonide, azathioprine (AZA), 6-mercaptopurine (6-MP), methotrexate, antibiotics, probiotics…