Curbside Consultation in IBD: 49 Clinical Questions, Second Edition

David T Rubin, MD; Sonia Friedman, MD; Francis A Farraye, MD MSc

Question 40: How Do You Screen And Survey For Dysplasia In Crohn’S Disease Patients? Can You Perform Segmental Resection In Crohn’S Disease Patients With Dysplasia? (continued)

Sonia Friedman, MD

Population- and hospital-based studies that span the past 35 years support an increased risk of colon cancer in patients with Crohn’s disease (CD).1,2 However, many of these studies do not separate out the patients who are specifically at risk: those with extensive Crohn’s colitis. It is impossible to compare the risk of colon cancer in CD to that in ulcerative colitis (UC) unless patients with equal extent and duration of disease are studied. Patients with only ileal or gastroduodenal disease have never been shown to have an increased risk of colorectal cancer. In studies that…