Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 14: 6-Mercaptopurine and Azathioprine in Crohn's Disease (continued)

Mark T. Osterman, MD; Gary R. Lichtenstein, MD, FACP, FACG, AGAF

In this chapter, the clinical efficacy of 6-MP and AZA in CD will be discussed at length first. Specifically, clinical trial data regarding their use in the induction of remission, maintenance of remission (including postoperative), treatment of fistulizing disease, corticosteroid sparing, and minimization of immunogenicity to infliximab will be addressed. The other main section of the chapter will be devoted to the pharmacology of 6-MP and AZA. The metabolism, mechanism of action, pharmacokinetics, monitoring of metabolite levels, dosing and duration of therapy, adverse effects, safety in…