Gut Instincts: A Clinician's Handbook of Digestive and Liver Diseases

Eric Esrailian, MD, MPH

Chapter 17: Crohn’S Disease (continued)

Marla Dubinsky, MD

Crohn’s disease (CD) is characterized by chronic intestinal inflammation. The exact etiology remains unclear; however, research continues to advance at a rapid pace to try and uncover the mysteries of this heterogeneous inflammatory process. Two important discoveries have been made in the past decade: the role of genetic susceptibility in CD and the introduction of monoclonal antibodies targeted to tumornecrosis factor alpha (TNFα). This chapter will highlight advances in the diagnosis and management of CD and how genetics is shaping the individualization of treatment approaches…