Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 25: Management of Refractory Crohn’s Disease (continued)

Herbert Tilg, MD; Arthur Kaser , MD

A common and challenging problem is the patient who, regardless of disease location, remains symptomatic despite adequate doses of steroids (steroid-resistant), 5-aminosalicylic acid (5-ASA) agents, and antibiotics or the patient who flares once corticosteroids are decreased or stopped (steroid-dependent). Currently, the main therapeutic options for those patients are immunosuppressants such as azathioprine (AZA) or 6-mercaptopurine (6-MP). Chapters 15 and 16 cover all details regarding immunosuppressive treatment, and therefore these aspects are covered only briefly. This section will…