Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 16: Calcineurin Inhibitors (Cyclosporine A, Tacrolimus, and Sirolimus) and Mycophenolate Mofetil in Crohn’s Disease (continued)

Gerassimos J. Mantzaris, MD, PhD, AGAF

Patients with active steroid-refractory or steroid-dependent CD in whom the use of conventional immune modulators such as azathioprine (AZA), 6-mercaptopurine (6-MP), or methotrexate is precluded by slow onset of action, lack of response, or intolerance, are currently treated with rapidly acting anti-tumor necrosis factor alpha (TNF ) agents such as infliximab. Patients who fail to respond to all these therapies may benefit from the use of calcineurin inhibitors or mycophenolate mofetil either as rescue or adjunctive immunosuppressive therapy. Calcineurin inhibitors (cyclosporine or CyA…