Crohn's Disease: The Complete Guide to Medical Management

Gary R. Lichtenstein, MD, FACP, FACG, AGAF

Chapter 29: Management of Crohn’s Disease in the Ileal-Pouch Anal Anastomosis (continued)

Gilaad G. Kaplan, MD, FRCP(C); Remo Panaccione, MD, FRCP(C)

Medical therapy for UC is limited to sulfasalazine, 5-aminosalicylic acid (5-ASA), corticosteroids, and azathioprine (AZA). Refractory patients may be hospitalized and treated with IV glucocorticoids and occasionally intravenous (IV) cyclosporine. The latter is associated with a significant toxicity, and the long-term results have been variable. Arguably, the most significant advance in the treatment of UC in the past 2 decades has been the development and expanded use of the proctocolectomy with ileal pouch-anal anastomosis (IPAA) formation.1 Although most UC patients with an IPAA do…