Common Liver Diseases and Transplantation: An Algorithmic Approach to Work Up and Management

Robert S Brown Jr, MD MPH

Chapter 2: Medical Care And Special Considerations For Patients With Advanced Liver Disease/Cirrhosis (continued)

Eva Urtasun Sotil, MD

DEFINITION, EPIDEMIOLOGY, CAUSES, NATURAL HISTORY, AND PROGNOSIS Cirrhosis is defined as the presence of anatomic distortion of the liver parenchyma due to fibrosis deposition with formation of regenerative nodules. It is the final stage of many liver conditions in which persistent inflammation affects the liver parenchyma. The exact prevalence of cirrhosis in the United States is unknown. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) data estimated the prevalence at 0.15% for the years 1976 to 1980.1 This number is thought to underrepresent the true prevalence…